Linked Life Data

2358661

Source:http://linkedlifedata.com/resource/pubmed/id/2358661

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-8-1
pubmed:abstractText
Morphometric analysis of the population of synapses in medial prefrontal cortex (layer VI) of rat treated daily with haloperidol in a dose of 1.0 mg/kg during 3 weeks was performed on the electronmicroscopic level. The density of synapses on dendritic shafts increased on 29% and on the head of spine it increased on 20%. Nearly all the parameters measured in axo-spinous synapses were significantly decreased (area of presynaptic terminal, summarized area of mitochondriae per terminal, number of synaptic vesicles near the active zone, area of postsynaptic spine). There were no differences between the parameters of axo-dendritic synapses in control and haloperidol-treated rats. The data suggest that haloperidol might have induced the formation of the new synapses and may have changed the efficacy of the synaptic transmission in axo-spinous synapses on the head of spine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0021-8359
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Synaptic plasticity in rat medial prefrontal cortex under chronic haloperidol treatment produced behavioral sensitization.
pubmed:affiliation
All-Union Research Center of Mental Health, Academy of Medical Science, USSR.
pubmed:publicationType
Journal Article