Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-7-31
|
| pubmed:abstractText |
A retrospective analysis was performed to determine the surgical outcome and long-term follow-up of patients with documented cystic medial necrosis of the aorta. Ninety-three patients were diagnosed as having cystic medial necrosis at the Cleveland Clinic between July 1963 and December 1987 (72% men aged 26 to 77 years, mean 55). Patients who met the standard diagnostic criteria for Marfan's syndrome were deliberately excluded. Sixty-eight percent of the patients had a diastolic murmur and chest roentgenogram revealed a dilated aortic arch in 58% and cardiomegaly in 63%. Cardiac catheterization in 76 patients demonstrated aortic root dilation in 78%, aortic regurgitation in 72%, aortic dissection in 32% and coronary artery disease in 32%. Ninety patients underwent surgery including composite graft repair with reimplantation of the coronary arteries in 34%. Follow-up, obtained on 90 (97%) of the 93 patients, ranged in duration from 0 to 137 months (mean 29). Thirty-four of the 90 patients died (age range 30 to 75 years, mean 60). Ninety-four percent of the known causes of death were related to the cardiovascular system; 65% were the result of aortic dissection or rupture or sudden death. Ninety-six percent of survivors were in New York Heart Association functional class I or II. Overall estimated survival at 1, 3 and 5 years was 72.2%, 63.5% and 57.4%, respectively. Actuarial survival in patients who underwent composite graft reconstruction was 84% at 5 years. The presence of a diastolic murmur at initial presentation was associated with a poor prognosis (p = 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0735-1097
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
68-73
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:2358606-Adult,
pubmed-meshheading:2358606-Aged,
pubmed-meshheading:2358606-Aortic Diseases,
pubmed-meshheading:2358606-Cardiovascular Diseases,
pubmed-meshheading:2358606-Cause of Death,
pubmed-meshheading:2358606-Cysts,
pubmed-meshheading:2358606-Emergencies,
pubmed-meshheading:2358606-Female,
pubmed-meshheading:2358606-Follow-Up Studies,
pubmed-meshheading:2358606-Heart Murmurs,
pubmed-meshheading:2358606-Humans,
pubmed-meshheading:2358606-Male,
pubmed-meshheading:2358606-Marfan Syndrome,
pubmed-meshheading:2358606-Middle Aged,
pubmed-meshheading:2358606-Necrosis,
pubmed-meshheading:2358606-Prevalence,
pubmed-meshheading:2358606-Prognosis,
pubmed-meshheading:2358606-Retrospective Studies,
pubmed-meshheading:2358606-Survival Analysis
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Cystic medial necrosis of the aorta in patients without Marfan's syndrome: surgical outcome and long-term follow-up.
|
| pubmed:affiliation |
Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195-5066.
|
| pubmed:publicationType |
Journal Article
|