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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-7-31
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pubmed:abstractText |
Acidic fibroblast growth factor (aFGF) induced a large increase in the type II 5'-deiodinase (5'D) activity in astroglial cells. This required a time lag of about 4 h. Half-maximal stimulation was obtained with about 7 ng/ml aFGF. This factor at 20 ng/ml induced several times more 5'D activity than did 20 ng/ml basic fibroblast growth factor (bFGF) after 8 h incubation. aFGF (20 ng/ml) produced a 10-50-fold increase in 5'D activity after 24 h, whereas the effect of 20 ng/ml bFGF had disappeared after 24 h. Heparin (17 micrograms/ml) potentiated the 5'D response to natural and recombinant aFGF. Glucocorticoids amplified the aFGF-induction of 5'D activity. This is the first demonstration in astroglial cells that a growth factor can regulate the 5'D activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0165-3806
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
237-42
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2357797-Animals,
pubmed-meshheading:2357797-Astrocytes,
pubmed-meshheading:2357797-Brain,
pubmed-meshheading:2357797-Cells, Cultured,
pubmed-meshheading:2357797-Enzyme Activation,
pubmed-meshheading:2357797-Fibroblast Growth Factors,
pubmed-meshheading:2357797-Heparin,
pubmed-meshheading:2357797-Hydrocortisone,
pubmed-meshheading:2357797-Hydrogen-Ion Concentration,
pubmed-meshheading:2357797-Iodide Peroxidase,
pubmed-meshheading:2357797-Rats,
pubmed-meshheading:2357797-Rats, Inbred Strains,
pubmed-meshheading:2357797-Recombinant Proteins
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pubmed:year |
1990
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pubmed:articleTitle |
Induction of 5'-deiodinase activity in rat astroglial cells by acidic fibroblast growth factor.
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pubmed:affiliation |
Unité de Recherche sur la Glande Thyroïde et la Régulation Hormonale, Institut National de la Santé et de la Recherche Médicale, Kremlin-Bicêtre, France.
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pubmed:publicationType |
Journal Article
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