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rdf:type |
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lifeskim:mentions |
umls-concept:C0017071,
umls-concept:C0021289,
umls-concept:C0027752,
umls-concept:C0027754,
umls-concept:C0034693,
umls-concept:C0041491,
umls-concept:C0205263,
umls-concept:C0220781,
umls-concept:C0220806,
umls-concept:C0442805,
umls-concept:C0449468,
umls-concept:C1883254,
umls-concept:C2349975
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pubmed:issue |
2
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pubmed:dateCreated |
1975-6-25
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pubmed:abstractText |
Concomitant daily treatment of newborn rats for a 2-week to 1-month period with 10 mug/g of body weight of nerve growth factor and 100 mug/g of body weight of 6-hydroxydopamine produces in the cell bodies of adrenergic neurons the characteristic effects of the growth factor but in the nerve terminals the characteristic effects of 6-hydroxydopamine. The dual opposite effects result in a striking volume increase of sympathetic ganglia which far exceeds that produced by nerve growth factor alone. The selective induction of tyrosine hydroxylase [L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] in these chemically axotomized adrenergic neurons is even more pronounced than that produced by nerve growth factor alone in intact neurons.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-14075717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-14335680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-4124177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-4387076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-4388102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-4399447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-4552142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-4576887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-4982360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-5263743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-5283951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-5338067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-5804613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-6053599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/235759-6062892
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
595-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:235759-Animals,
pubmed-meshheading:235759-Animals, Newborn,
pubmed-meshheading:235759-Axons,
pubmed-meshheading:235759-Ganglia, Autonomic,
pubmed-meshheading:235759-Hydroxydopamines,
pubmed-meshheading:235759-Nerve Growth Factors,
pubmed-meshheading:235759-Neurons,
pubmed-meshheading:235759-Rats,
pubmed-meshheading:235759-Sympathectomy,
pubmed-meshheading:235759-Tyrosine 3-Monooxygenase
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pubmed:year |
1975
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pubmed:articleTitle |
Nerve growth factor induces volume increase and enhances tyrosine hydroxylase synthesis in chemically axotomized sympathetic ganglia of newborn rats.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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