Linked Life Data

2357571

Source:http://linkedlifedata.com/resource/pubmed/id/2357571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1990-8-1
pubmed:abstractText
The intrathecal administration of the opiate antagonist naloxone produced a dose-dependent biphasic change in mechanical nociceptive threshold, in the rat hindpaw. Lower doses (50 pg to 500 ng) produced analgesia while higher doses (5 to 50 micrograms) resulted in successively less analgesia. In contrast, the intracerebroventricular administration of naloxone up to a dose of 5 micrograms (i.e. a dose 10,000 times greater than that required to produce a maximal analgesic effect) only produced analgesia. The ability to differentiate between the analgesic and pain-enhancing properties of naloxone by administration at different anatomical sites is compatible with the suggestion that the analgesic and pain-enhancing effects of naloxone are produced by separate mechanisms of action.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
515
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Intracerebroventricular naloxone produces a dose-dependent, monotonic increase in nociceptive threshold in the rat.
pubmed:affiliation
School of Nursing, University of California, San Francisco 94143.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't