Linked Life Data

2357249

Source:http://linkedlifedata.com/resource/pubmed/id/2357249

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-7-26
pubmed:abstractText
The antitumor activity of a few 1-nitro-9-aminoacridine derivatives including nitracrine was evaluated against ascitic forms of murine tumors: Ehrlich carcinoma. Walker carcinosarcoma 256, and leukemia L1210. The studied compounds exhibited significant activity against ascitic Ehrlich carcinoma and very high activity against Walker carcinosarcoma. Leukemia L1210 on mice was not sensitive to the 1-nitro derivatives studied. On the basis of these results and the results reported earlier the following, specific biological properties exhibited by the derivatives studied were discussed: a) high activity against HeLa S3 and L1210 cells in vitro, but lack of activity against mice leukemia L1210; b) significant activity against some experimental and clinical tumors but not against leukemias, and c) lack of mammalian myelotoxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
472-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Antitumor activity of 1-nitro-9-aminoacridines including nitracrine against some ascitic experimental tumors.
pubmed:affiliation
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't