| pubmed-article:2356860 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C0221928 | lld:lifeskim |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C1326347 | lld:lifeskim |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:2356860 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:2356860 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2356860 | pubmed:dateCreated | 1990-7-24 | lld:pubmed |
| pubmed-article:2356860 | pubmed:abstractText | Human dermal fibroblasts failed to proliferate when cultured in medium containing 0.15 mmol/l (millimolar) Ca2+ (keratinocyte growth medium [KGM]) but did when the external Ca2+ concentration was raised to 1.4 mmol/l. All-trans retinoic acid (retinoic acid) stimulated proliferation in KGM but did not further stimulate growth in Ca2(+)-supplemented KGM. The ability of retinoic acid to stimulate proliferation was inhibited in KGM prepared without Ca2+ or prepared with 0.03 mmol/l Ca2+ and in KGM treated with 1 mmol/l ethylene-glycol-bis-(beta-aminoethyl ether)N,N'-tetra acetic acid. Using 45Ca2+ to measure Ca2+ influx and efflux, it was found that retinoic acid minimally increased Ca2+ uptake into fibroblasts. In contrast, retinoic acid treatment of fibroblasts that had been pre-equilibrated for 1 day with 45Ca2+ inhibited release of intracellular Ca2+ into the extracellular fluid. Retinoic acid also stimulated 35S-methionine incorporation into trichloroacetic acid-precipitable material but in contrast to its effect on proliferation, stimulation of 35S-methionine incorporation occurred in both high-Ca2+ and low-Ca2+ medium. These data indicate that retinoic acid stimulation of proliferation, but not protein synthesis, is dependent on the concentration of Ca2+ in the extracellular environment. | lld:pubmed |
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| pubmed-article:2356860 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2356860 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2356860 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2356860 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2356860 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:2356860 | pubmed:author | pubmed-author:VoorheesJ JJJ | lld:pubmed |
| pubmed-article:2356860 | pubmed:author | pubmed-author:PerryDD | lld:pubmed |
| pubmed-article:2356860 | pubmed:author | pubmed-author:VaraniJJ | lld:pubmed |
| pubmed-article:2356860 | pubmed:author | pubmed-author:MitraR SRS | lld:pubmed |
| pubmed-article:2356860 | pubmed:author | pubmed-author:NickoloffB... | lld:pubmed |
| pubmed-article:2356860 | pubmed:author | pubmed-author:ShayevitzJJ | lld:pubmed |
| pubmed-article:2356860 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2356860 | pubmed:volume | 136 | lld:pubmed |
| pubmed-article:2356860 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2356860 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2356860 | pubmed:pagination | 1275-81 | lld:pubmed |
| pubmed-article:2356860 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2356860 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2356860 | pubmed:articleTitle | Retinoic acid stimulation of human dermal fibroblast proliferation is dependent on suboptimal extracellular Ca2+ concentration. | lld:pubmed |
| pubmed-article:2356860 | pubmed:affiliation | Department of Pathology, University of Michigan Medical School, Ann Arbor 48109. | lld:pubmed |
| pubmed-article:2356860 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2356860 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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