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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-7-26
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pubmed:abstractText |
Yang et al. (14) have isolated from mammalian brain an octapeptide FLFQPQRF-NH2 (F-8-F-NH2) with certain antiopiate properties. Third ventricular injection of 2 micrograms of this peptide together with the aminopeptidase inhibitor bestatin precipitated an opiate-withdrawal syndrome in morphine-dependent but not in nondependent rats. Third ventricular injection in nondependent rats of 15 micrograms of the peptide together with bestatin induced a morphine-withdrawal-like behavioral syndrome. This syndrome was not produced by injection of bestatin or saline vehicle alone and was preventable by injection of 3.5 mg/kg morphine sulphate SC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2356156-Analysis of Variance,
pubmed-meshheading:2356156-Animals,
pubmed-meshheading:2356156-Double-Blind Method,
pubmed-meshheading:2356156-Injections, Intraventricular,
pubmed-meshheading:2356156-Leucine,
pubmed-meshheading:2356156-Male,
pubmed-meshheading:2356156-Morphine,
pubmed-meshheading:2356156-Neuropeptides,
pubmed-meshheading:2356156-Oligopeptides,
pubmed-meshheading:2356156-Random Allocation,
pubmed-meshheading:2356156-Rats,
pubmed-meshheading:2356156-Rats, Inbred Strains,
pubmed-meshheading:2356156-Substance Withdrawal Syndrome
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pubmed:articleTitle |
FMRF-NH2-like mammalian peptide precipitates opiate-withdrawal syndrome in the rat.
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pubmed:affiliation |
University of Houston-Clear Lake, TX 77058.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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