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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1990-7-20
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pubmed:abstractText |
A 114-base-pair promoter fragment of the human porphobilinogen deaminase gene functioned in an erythroid-specific manner in transient transfection experiments. Site-directed mutagenesis of the binding site for the erythroid-specific transcription factor (NF-E1) or an adjacent CACCC motif abolished the promoter activity. Increasing the spacing between these sites progressively reduced promoter activity, but there was no evidence that a critical alignment of the two factors on the DNA helix was required.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-2461328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-2612916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-2768242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-2771941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-2831456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-2911469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-2911489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-2922281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3001535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3023965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3132708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3166139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3181130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3201230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3243278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3413070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3422099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3422427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3627254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3672119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3774543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-3881765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-390497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-6099327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2355926-6302193
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3838-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2355926-Ammonia-Lyases,
pubmed-meshheading:2355926-Base Sequence,
pubmed-meshheading:2355926-Binding Sites,
pubmed-meshheading:2355926-Chromosome Deletion,
pubmed-meshheading:2355926-DNA-Binding Proteins,
pubmed-meshheading:2355926-Erythroid-Specific DNA-Binding Factors,
pubmed-meshheading:2355926-Gene Expression Regulation,
pubmed-meshheading:2355926-Genes,
pubmed-meshheading:2355926-Genetic Vectors,
pubmed-meshheading:2355926-Humans,
pubmed-meshheading:2355926-Hydroxymethylbilane Synthase,
pubmed-meshheading:2355926-Molecular Sequence Data,
pubmed-meshheading:2355926-Mutation,
pubmed-meshheading:2355926-Oligonucleotide Probes,
pubmed-meshheading:2355926-Promoter Regions, Genetic,
pubmed-meshheading:2355926-Transcription Factors,
pubmed-meshheading:2355926-Transfection
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pubmed:year |
1990
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pubmed:articleTitle |
Synergy between the NF-E1 erythroid-specific transcription factor and the CACCC factor in the erythroid-specific promoter of the human porphobilinogen deaminase gene.
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pubmed:affiliation |
Cancer Research Campaign Beatson Laboratories, Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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