Linked Life Data

2353135

Source:http://linkedlifedata.com/resource/pubmed/id/2353135

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-7-16
pubmed:abstractText
Cell injury due to hypoxia and reoxygenation was studied in primary cultured rat Kupffer cells. Under hypoxic conditions only 20% of the cells had lost their viability after 12 h of incubation. In contrast, almost complete losses of cell viability were observed when reoxygenation was performed after 2, 4 or 6 h of hypoxia. The time-course of reoxygenation injury in Kupffer cells was characterized by a lag phase of 2 h during which no difference between reoxygenated and hypoxically incubated cells was apparent; during the next 4 h, there was an increase of up to 100% in the amount of nonviable cells in the reoxygenated cultures. These results indicate that Kupffer cells were much more vulnerable to reoxygenation than to hypoxia. The time-course of cell damage upon hypoxia/reoxygenation may indicate a self-destruction mechanism caused by an oxygen-triggered activation of these cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
263-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Hypoxia/reoxygenation injury in liver: Kupffer cells are much more vulnerable to reoxygenation than to hypoxia.
pubmed:affiliation
Klinische Forschergruppe Leberschädigung, Universität Düsseldorf, F.R.G.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't