Linked Life Data

2352836

Source:http://linkedlifedata.com/resource/pubmed/id/2352836

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pubmed-article:2352836pubmed:abstractTextAt low concentrations (up to 5 mM) the compound 2,3-butanedione monoxime (BDM) was found to reduce twitch tension and initial heat production in isolated papillary muscles without significantly affecting the size of the intracellular Ca2+ transient measured with aequorin luminescence. Higher concentrations of BDM caused further inhibition of twitch tension and heat production with a fall in the size of the Ca2+ transient. The size of the aequorin transient was 50% of the control value at 15 mM BDM while twitch tension was negligible. These results suggest that BDM selectively inhibits Ca2+ activated force in cardiac muscle at low concentrations with additional effects on intra-cellular calcium at concentrations above 5 mM.lld:pubmed
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pubmed-article:2352836pubmed:articleTitleThe effects of 2,3-butanedione monoxime on initial heat, tension, and aequorin light output of ferret papillary muscles.lld:pubmed
pubmed-article:2352836pubmed:affiliationDepartment of Physiology, University of Vermont, Burlington 05405.lld:pubmed
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