Linked Life Data

2352448

Source:http://linkedlifedata.com/resource/pubmed/id/2352448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-7-13
pubmed:abstractText
Airways resistance to electrical field stimulation of the vagus nerves was applied to study the efficacies of atropine and trospium chloride in anesthetized guinea pigs. Stimulation induced an airways resistance that was reproducible, thereby significantly lowering blood pressure and reducing heart rate (p less than 0.05). The induced airways resistance was antagonized using 5 micrograms/kg of either atropine or trospium, but was unaffected by physiological sodium chloride solution. At the dose 10 micrograms/kg, trospium chloride was significantly more potent than atropine which showed only slight augmentation in activity. The present results demonstrate that this procedure can be utilized to investigate, both qualitatively and quantitatively, the actions of anticholinergic and bronchospasmolytic agents in laboratory set-ups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0379-0355
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
A new method for determining bronchospasmolytic drug effects in vagotomized guinea pigs.
pubmed:affiliation
Dr. Madaus GmbH Co., Pharmakologie Abteilung, Cologne, Germany.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't