Linked Life Data

2352150

Source:http://linkedlifedata.com/resource/pubmed/id/2352150

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-7-16
pubmed:abstractText
We have shown that adsorbability of local anesthetics onto activated carbon, expressed by the partition coefficients at infinite dilution, correlated well with the pharmacological activity. However, there is no parameter that can singly express the tendency to be adsorbed. Adsorbability is a loosely defined term and its meaning varies with the adsorption model. This study showed that the logarithm of the adsorbed amount of drugs was linearly related to the logarithm of the free drug concentration, in conformity to the Freundlich adsorption isotherms. The slope of the double logarithmic plot is expressed by 1/N in the Freundlich equation and is considered to be inversely related to the drug affinity to the adsorbent. The slope was used to evaluate the tendency to be adsorbed, or "adsorbability" of seven aromatic amine local anesthetics. Phenobarbital was included to compare anionic drugs in contrast to the cationic local anesthetics. The slopes were nearly equal between the cationic and neutral local anesthetics. Apparently, the lower hydrophobicity of the cationic forms is compensated by the electrostatic attraction from the negative charges present on the activated carbon surface. With phenobarbital, the slope value of the anionic form was larger than the neutral form. The lower affinity of the anionic form may be caused by the electrostatic repulsion. The molecular size parameters (i.e., molecular weight, molar refraction, and parachor) showed a linear relationship to the slope values. It may be possible to estimate the affinity-related slope values from these parameters.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
354-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Adsorption of local anesthetics on activated carbon: Freundlich adsorption isotherms.
pubmed:affiliation
Department of Anesthesia, University of Utah School of Medicine, Salt Lake City 84132.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.