Linked Life Data

2351439

Source:http://linkedlifedata.com/resource/pubmed/id/2351439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 2
pubmed:dateCreated
1990-7-13
pubmed:abstractText
Left ventricular dP/dt has been reported to be enhanced in the perfused isovolumic paced heart (Langendorff preparation) isolated from sodium-depleted rats. In this study, we tested the hypothesis that this positive inotropic effect is caused by increased responsiveness of the contractile myofilaments to calcium. To address this question, the calcium-left ventricular pressure relation during tetanization of the whole heart at different extracellular calcium concentrations (2.5, 5.0, 7.5, 12.5, and 15.0 mM) was studied in 19 sodium-depleted (low sodium diet plus diuretics) and 18 control (regular sodium intake) Sprague-Dawley normotensive rats. Results showed that the maximum calcium-activated left ventricular pressure (induced by tetanization) was significantly higher in sodium-depleted than in control rats at 12.5 mM calcium concentration (170 +/- 27 [SD] mm Hg in sodium-depleted rats vs. 112 +/- 14 mm Hg in control rats, p = 0.0005). The calcium concentration at which half-maximal left ventricular pressure response was attained, however, was not different between the two groups. We conclude that long-term in vivo sodium depletion increased the maximum calcium-activated left ventricular pressure without altering the sensitivity of the contractile machinery to calcium.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0194-911X
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
894-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Sodium depletion increases calcium-activated left ventricular pressure in the rat.
pubmed:affiliation
Department of Heart and Hypertension Research, Cleveland Clinic Foundation, Ohio 44195-5069.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't