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rdf:type |
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lifeskim:mentions |
umls-concept:C0162326,
umls-concept:C0205275,
umls-concept:C0205341,
umls-concept:C0242210,
umls-concept:C0439064,
umls-concept:C0439855,
umls-concept:C0449432,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1704256,
umls-concept:C1705248
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pubmed:issue |
6
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pubmed:dateCreated |
1990-7-18
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pubmed:databankReference |
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pubmed:abstractText |
TGF-beta occurs in a latent complex of high Mr. We report the cDNA cloning and an initial structural and functional characterization of a component of the large latent TGF-beta 1 complex, denoted TGF-beta 1 binding protein (TGF-beta 1-BP). Most of the sequence of fibroblast TGF-beta 1-BP is made up of cysteine-rich repeats of two different kinds; there are 16 EGF-like repeats and three repeats with a distant resemblance to EGF, but of a distinct type hitherto not found in any other protein. beta-hydroxylated asparagine residues were identified in two of the EGF-like repeats. TGF-beta 1-BP purified from human platelets is considerably smaller than the fibroblast form (125-160 kd vs. 170-190 kd), suggesting that there is alternative splicing of the TGF-beta 1-BP gene or that TGF-beta 1-BP undergoes cell-specific proteolysis. TGF-beta 1-BP was found not to bind and inactive TGF-beta 1; its role in the latent complex is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1051-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2350783-Amino Acid Sequence,
pubmed-meshheading:2350783-Animals,
pubmed-meshheading:2350783-Asparagine,
pubmed-meshheading:2350783-Base Sequence,
pubmed-meshheading:2350783-Blood Platelets,
pubmed-meshheading:2350783-Blotting, Northern,
pubmed-meshheading:2350783-Carrier Proteins,
pubmed-meshheading:2350783-Cell Line,
pubmed-meshheading:2350783-Cloning, Molecular,
pubmed-meshheading:2350783-DNA,
pubmed-meshheading:2350783-Gene Expression,
pubmed-meshheading:2350783-Humans,
pubmed-meshheading:2350783-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:2350783-Latent TGF-beta Binding Proteins,
pubmed-meshheading:2350783-Molecular Sequence Data,
pubmed-meshheading:2350783-Nucleic Acid Hybridization,
pubmed-meshheading:2350783-Peptide Fragments,
pubmed-meshheading:2350783-RNA, Messenger,
pubmed-meshheading:2350783-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:2350783-Transforming Growth Factors
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pubmed:year |
1990
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pubmed:articleTitle |
TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden.
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pubmed:publicationType |
Journal Article
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