Linked Life Data

2350086

Source:http://linkedlifedata.com/resource/pubmed/id/2350086

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1990-7-9
pubmed:abstractText
A new clinicopathologic entity, diffuse panbronchiolitis, was recently reported in Japan. This disorder is characterized by recurrent sinopulmonary infection and respiratory bronchiolitis. We identified cases of familial diffuse panbronchiolitis and found that many siblings of the patients had paranasal sinusitis. Because of this, we performed HLA analysis of the patients with diffuse panbronchiolitis. In HLA Class I and Class II antigens, Bw54 significantly increased (frequency: 63.2%; RR = 13.30; corrected p value less than 1.08 x 10(-10], whereas Cw1 and MC1 (a new HLA-DR-related antigen) slightly increased. These increases might be explained by the fact that these two antigens, Cw1 and MC1, formed a haplotype with Bw54, which suggests that one or some of the genes controlling the susceptibility and/or immune responsiveness of diffuse panbronchiolitis might be located near HLA loci. In addition, Bw54, or its related haplotype, exists only in Japanese, Chinese, and Korean populations. This may explain why a similar disease had not been reported in the English literature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1459-62
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Analysis of HLA antigens in patients with diffuse panbronchiolitis.
pubmed:affiliation
Division of Pulmonary Disease, Tokyo Metropolitan Komagome Hospital, Japan.
pubmed:publicationType
Journal Article