Linked Life Data

2349553

Source:http://linkedlifedata.com/resource/pubmed/id/2349553

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-7-12
pubmed:abstractText
Nonpulsatile perfusion techniques with extracorporeal circulation for open-heart surgery and aortocoronary bypass grafting are widely used; this treatment is often followed by temporary or permanent neurological deficits. Experimental studies suggest that pulsatile flow may be of greater benefit because of its ability to ameliorate cerebral microcirculation. We therefore investigated 22 men who underwent aortocoronary bypass grafting. Patients were randomly divided into either a group undergoing nonpulsatile (n = 14) or pulsatile flow (n = 8). Neurological examinations were done prior to the operation and on the 7th postoperative day. EEG, cerebral blood flow (CBF), and the metabolic rates of O2 (CMR O2) and glucose (CMR Glucose) were measured before anaesthesia and 30 minutes after the start of extracorporeal circulation, when venous blood temperature was 26 degrees C. Postoperative neurological symptoms consisted of cranial nerve palsies, dysfunctions of the visual cortex, cerebellar symptoms, and slight arm paresis, but no differences between the two treatment groups were detected. Moreover, changes in EEG, CBF, and CMR rates during anaesthesia did not differ between the two groups. Our data suggest that pulsatile flow is not superior to the nonpulsatile perfusion technique, but to confirm this larger patient samples are required.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0171-6425
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Cerebral dysfunction following extracorporeal circulation for aortocoronary bypass surgery: no differences in neuropsychological outcome after pulsatile versus nonpulsatile flow.
pubmed:affiliation
Department of Neurology, University Hospital Göttingen, FRG.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial