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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1990-7-12
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pubmed:abstractText |
Autonomic neuropathy and urinary bladder function were compared in Sprague-Dawley rats with alloxan-diabetes of 3 months duration, rats fed sucrose for 8 weeks, and rats examined 8 weeks after pelvic nerve surgical axotomy; normal age-matched rats were used as controls. All experimental interventions induced bladder hypertrophy with increased bladder weight. In diabetic and sucrose-fed animals, water intake and urinary output increased. Cystometric recordings of normal rats in vivo showed rhythmic contractions (1.25 +/- 0.25 contr/min) with threshold volume for micturition reflex at 0.51 +/- 0.04 ml. In diabetic rats, bladder contractions were irregular and of lower frequency (0.60 +/- 0.04 contr/min), while threshold volume was significantly higher (1.00 +/- 0.11 ml). Bladder contractions were normal in sucrose-fed animals, though threshold volume was markedly augmented (1.27 +/- 0.19 ml). Pelvic nerve surgical ablation abolished micturition reflex. In bladder strips excised post-mortem, contractile response to field stimulation was reduced in diabetic rats compared to control and sucrose-fed animals. Morphological examination of pelvic and hypogastric nerves revealed abnormalities characteristic of diabetic neuropathy only in diabetic rats. These data suggest that in alloxan-induced diabetes the decrease in the rate of bladder contraction is the result of autonomic neuropathy; while bladder hypertrophy in sucrose-fed rats appears to be an organ adaptation to hyperdiuresis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0165-1838
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2348050-Alloxan,
pubmed-meshheading:2348050-Animals,
pubmed-meshheading:2348050-Autonomic Nervous System Diseases,
pubmed-meshheading:2348050-Diabetes Mellitus, Experimental,
pubmed-meshheading:2348050-Diabetic Neuropathies,
pubmed-meshheading:2348050-Electric Stimulation,
pubmed-meshheading:2348050-Endoscopy,
pubmed-meshheading:2348050-Hypogastric Plexus,
pubmed-meshheading:2348050-Male,
pubmed-meshheading:2348050-Microscopy, Electron,
pubmed-meshheading:2348050-Nervous System,
pubmed-meshheading:2348050-Pelvis,
pubmed-meshheading:2348050-Rats,
pubmed-meshheading:2348050-Rats, Inbred Strains,
pubmed-meshheading:2348050-Stimulation, Chemical,
pubmed-meshheading:2348050-Urinary Bladder
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pubmed:year |
1990
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pubmed:articleTitle |
Cystometric changes in alloxan diabetic rats: evidence for functional and structural correlates of diabetic autonomic neuropathy.
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pubmed:affiliation |
Department of Neurocardiovascular Research, Fidia Research Laboratories, Abano Terme, Italy.
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pubmed:publicationType |
Journal Article
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