Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1990-7-12
|
| pubmed:abstractText |
The role of the hippocampus (HPC) in trace eye-blink conditioning was evaluated using a 100-ms tone conditioned stimulus (CS), a 300- or 500-ms trace interval, and a 150-ms air puff unconditioned stimulus (UCS). Rabbits received complete hippocampectomy (dorsal & ventral), sham lesions, or neocortical lesions. Hippocampectomy produced differential effects in relation to the trace interval used. With a 300-ms trace interval, HPC-lesioned Ss showed profound resistance to extinction after acquisition. With a 500-ms trace interval, HPC-lesioned Ss did not learn the task (only 22% conditioned responses (CRs) after 25 sessions, whereas controls showed greater than 80% after 10 sessions), and on the few trials in which a CR occurred, most were "nonadaptive" short-latency CRs (i.e., they started during or just after the CS and always terminated prior to UCS onset). The authors conclude that the HPC encodes a temporal relationship between CS and UCS, and when the trace interval is long enough (e.g., 500 ms), that the HPC is necessary for associative learning of the conditioned eye-blink response.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0735-7044
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
104
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
243-52
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2346619-Animals,
pubmed-meshheading:2346619-Association Learning,
pubmed-meshheading:2346619-Brain Mapping,
pubmed-meshheading:2346619-Cerebral Cortex,
pubmed-meshheading:2346619-Conditioning, Eyelid,
pubmed-meshheading:2346619-Dominance, Cerebral,
pubmed-meshheading:2346619-Extinction, Psychological,
pubmed-meshheading:2346619-Hippocampus,
pubmed-meshheading:2346619-Learning,
pubmed-meshheading:2346619-Male,
pubmed-meshheading:2346619-Mental Recall,
pubmed-meshheading:2346619-Neurons,
pubmed-meshheading:2346619-Rabbits,
pubmed-meshheading:2346619-Reaction Time
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Hippocampectomy disrupts trace eye-blink conditioning in rabbits.
|
| pubmed:affiliation |
Department of Cell, Molecular, and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|