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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1990-7-2
|
| pubmed:abstractText |
The growth of Staphylococcus epidermidis sensu stricto and Staphylococcus saprophyticus on Memphis agar yielded up to 6 morphotypes with each strain. With S. epidermidis, one morphotype produced slime (rho) but became non-slime-producing (epsilon) at a high frequency. The slime-producing rho variants were methicillin-resistant and more virulent than methicillin-susceptible epsilon variants in an endocarditis model. With S. saprophyticus, phase variation was of higher frequency. Nitrosoguanidine mutagenesis produced a stable blue epsilon form that was more virulent than the parent in a mouse model of urinary tract infection. Mutants with the blue epsilon phenotype differed from gold epsilon parents in a variety of phenotypic properties, including increased resistance to oxacillin. These staphylococcal species have a high frequency of phase variation: Phase variants differ in antibiotic resistance and virulence, which is only partially correlated with suggested virulence factors such as slime production.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
161
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1153-69
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2345296-Animals,
pubmed-meshheading:2345296-Anti-Bacterial Agents,
pubmed-meshheading:2345296-Culture Media,
pubmed-meshheading:2345296-Disease Models, Animal,
pubmed-meshheading:2345296-Drug Resistance, Microbial,
pubmed-meshheading:2345296-Endocarditis, Bacterial,
pubmed-meshheading:2345296-Male,
pubmed-meshheading:2345296-Mice,
pubmed-meshheading:2345296-Microscopy, Electron,
pubmed-meshheading:2345296-Mutation,
pubmed-meshheading:2345296-Phagocytosis,
pubmed-meshheading:2345296-Phenotype,
pubmed-meshheading:2345296-Rats,
pubmed-meshheading:2345296-Rats, Inbred Strains,
pubmed-meshheading:2345296-Staphylococcal Infections,
pubmed-meshheading:2345296-Staphylococcus,
pubmed-meshheading:2345296-Staphylococcus epidermidis,
pubmed-meshheading:2345296-Urinary Tract Infections,
pubmed-meshheading:2345296-Virulence,
pubmed-meshheading:2345296-beta-Lactams
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Colonial morphology of staphylococci on Memphis agar: phase variation of slime production, resistance to beta-lactam antibiotics, and virulence.
|
| pubmed:affiliation |
Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|