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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1990-7-5
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pubmed:abstractText |
Estrogen causes dramatic long-term changes in the activity of the uterus. Here we report the molecular cloning of a small (700 base) uterine mRNA species capable of inducing a slow K+ current in Xenopus oocytes. The 130 amino acid protein encoded by this mRNA species has a predicted structure that does not resemble that of previously described voltage-dependent channels from mammalian sources. It is, however, similar to structural motifs found in certain prokaryotic ion channels. The induction of this mRNA by estrogen is rapid; this uterine mRNA species is not detectable in uteri from estrogen-deprived rats, but is substantially induced after 3 hr of estrogen treatment. These results support a critical role for regulation of ion channel expression by estrogen in the uterus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
807-12
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2344412-Amino Acid Sequence,
pubmed-meshheading:2344412-Animals,
pubmed-meshheading:2344412-Base Sequence,
pubmed-meshheading:2344412-Blotting, Northern,
pubmed-meshheading:2344412-Cell Membrane Permeability,
pubmed-meshheading:2344412-DNA Probes,
pubmed-meshheading:2344412-Electric Conductivity,
pubmed-meshheading:2344412-Estrogens,
pubmed-meshheading:2344412-Female,
pubmed-meshheading:2344412-Gene Expression Regulation,
pubmed-meshheading:2344412-Membrane Potentials,
pubmed-meshheading:2344412-Molecular Sequence Data,
pubmed-meshheading:2344412-Potassium,
pubmed-meshheading:2344412-Potassium Channels,
pubmed-meshheading:2344412-RNA, Messenger,
pubmed-meshheading:2344412-Rats,
pubmed-meshheading:2344412-Rats, Inbred Strains,
pubmed-meshheading:2344412-Uterus
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pubmed:year |
1990
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pubmed:articleTitle |
Estrogen induction of a small, putative K+ channel mRNA in rat uterus.
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pubmed:affiliation |
Department of Physiology and Biophysics, University of Iowa, Iowa City 52242.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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