Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1990-6-28
|
| pubmed:abstractText |
The mechanism of the internucleotide condensation and side-reactions in H-phosphonate approach has been investigated with the help of NMR-spectroscopy. On the basis of the results obtained a modification minimizing side-reactions in the course of the nucleotide component preactivation has been developed. It includes the use of acetonitrile--quinoline (4:1) mixture as the solvent in coupling reactions. The efficiency of the method is illustrated by the synthesis of oligodeoxynucleotides.
|
| pubmed:language |
rus
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0132-3423
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
211-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:2344385-Base Sequence,
pubmed-meshheading:2344385-Catalysis,
pubmed-meshheading:2344385-Chemical Phenomena,
pubmed-meshheading:2344385-Chemistry,
pubmed-meshheading:2344385-Methods,
pubmed-meshheading:2344385-Molecular Sequence Data,
pubmed-meshheading:2344385-Oligonucleotides,
pubmed-meshheading:2344385-Phosphonic Acids,
pubmed-meshheading:2344385-Phosphorylation,
pubmed-meshheading:2344385-Quinolines
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
[Modification of H-phosphonate method of oligonucleotide synthesis on polymer support].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|