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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1990-6-25
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pubmed:abstractText |
To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [18F]N-methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects. Cocaine abusers who had been detoxified for 1 week or less showed significantly lower values for uptake of [18F]N-methylspiroperidol in striatum than the normal subjects, whereas the cocaine abusers who had been detoxified for 1 month showed values comparable to those obtained from normal subjects. The authors conclude that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0002-953X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
147
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
719-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2343913-Adult,
pubmed-meshheading:2343913-Basal Ganglia,
pubmed-meshheading:2343913-Cocaine,
pubmed-meshheading:2343913-Corpus Striatum,
pubmed-meshheading:2343913-Down-Regulation,
pubmed-meshheading:2343913-Fluorine Radioisotopes,
pubmed-meshheading:2343913-Humans,
pubmed-meshheading:2343913-Receptors, Dopamine,
pubmed-meshheading:2343913-Spiperone,
pubmed-meshheading:2343913-Substance-Related Disorders,
pubmed-meshheading:2343913-Tomography, Emission-Computed,
pubmed-meshheading:2343913-Up-Regulation
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pubmed:year |
1990
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pubmed:articleTitle |
Effects of chronic cocaine abuse on postsynaptic dopamine receptors.
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pubmed:affiliation |
Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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