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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1990-6-27
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pubmed:abstractText |
Intracerebroventricular injections of [D-arginine2, sarcosine4]-dermorphin (1-4) (DAS-DER 1-4) and morphine produced a dose-dependent inhibition of the tail-flick response to thermal stimulation. The ED50 value for each drug was 3.23 (1.35-7.73) nmol/rat and 32.0 (13.3-76.6) nmol/rat, respectively. When injected into the spinal subarachnoid space, the ED50 value was 0.035 (0.015-0.086) nmol/rat for the tetrapeptide and 11.9 (5.7-25.2) nmol/rat for morphine, respectively. Antinociception induced by DAS-DER 1-4 and morphine, through the intracerebroventricular and intrathecal routes, was clearly reduced by pretreatment with a small dose of naloxone. After spinal transection, the antinociceptive potency of systemically-administered morphine was significantly reduced while that of DAS-DER 1-4 was unaltered. The activity of DAS-DER 1-4 and morphine was also reversed by naloxone in spinal animals. It is concluded that DAS-DER 1-4, a dermorphin analogue, has a minor supraspinal action but acts mainly at the level of the spinal cord, in contrast to the action of morphine.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/dermorphin (1-4), Arg(2)-Sar(4)-
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-3908
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2342636-Analgesics,
pubmed-meshheading:2342636-Animals,
pubmed-meshheading:2342636-Decerebrate State,
pubmed-meshheading:2342636-Injections,
pubmed-meshheading:2342636-Injections, Intraventricular,
pubmed-meshheading:2342636-Injections, Spinal,
pubmed-meshheading:2342636-Injections, Subcutaneous,
pubmed-meshheading:2342636-Male,
pubmed-meshheading:2342636-Morphine,
pubmed-meshheading:2342636-Naloxone,
pubmed-meshheading:2342636-Oligopeptides,
pubmed-meshheading:2342636-Rats,
pubmed-meshheading:2342636-Rats, Inbred Strains,
pubmed-meshheading:2342636-Reaction Time,
pubmed-meshheading:2342636-Subarachnoid Space
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pubmed:year |
1990
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pubmed:articleTitle |
Spinal antinociception: comparison of a dermorphin tetrapeptide analogue, [D-arginine2, sarcosine4]-dermorphin (1-4) and morphine in rats.
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pubmed:affiliation |
Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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