| pubmed-article:2342605 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2342605 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:2342605 | lifeskim:mentions | umls-concept:C0205042 | lld:lifeskim |
| pubmed-article:2342605 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:2342605 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:2342605 | lifeskim:mentions | umls-concept:C0201925 | lld:lifeskim |
| pubmed-article:2342605 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:2342605 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:2342605 | lifeskim:mentions | umls-concept:C0031584 | lld:lifeskim |
| pubmed-article:2342605 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:2342605 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2342605 | pubmed:dateCreated | 1990-6-27 | lld:pubmed |
| pubmed-article:2342605 | pubmed:abstractText | The effects of phorbol 12,13-dibutyrate (PDBu). a protein kinase C activator, on the tone and intracellular calcium level (Cai2+) of vascular smooth muscles were simultaneously measured by use of a force-displacement transducer and the fura-2 microscopic fluorometric technique in porcine coronary arteries. Cumulatively applied PDBu produced a slowly developing and concentration-dependent contraction in the concentration range of 10(-8)-10(-6) mol/l. Contractions induced by PDBu were sustained after removal of PDBu. Changes in Cai2+ produced by PDBu were very slight, although Cai2+ was increased at lower concentrations (3 x 10(-8) and 10(-7) mol/l) and decreased at higher concentrations (3 x 10(-7) and 10(-6) mol/l). Verapamil 10(-6) mol/l partially inhibited the contractions throughout the concentration range of PDBu and the increase in Cai2+ induced by lower concentrations of PDBu. When the effects of PDBu were compared with those of the 90 mmol/l KCl medium, the force of contraction induced by a single concentration of 10(-7) mol/l PDBu was about 50% and the increase in Cai2+ was about 10%. Removal of extracellular calcium by 1 mmol/l EGTA decreased Cai2+ by about 20% but vascular tone did not change. PDbu (10(-7) mol/l) produced a small contraction without an increase in Cai2+ in the Ca2+-free medium. Depolarization by the 20 mmol/l KCl medium increased Cai2+ by about 20%, whereas vascular tone did not change.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:2342605 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2342605 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342605 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2342605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342605 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2342605 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2342605 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2342605 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:2342605 | pubmed:author | pubmed-author:MoriTT | lld:pubmed |
| pubmed-article:2342605 | pubmed:author | pubmed-author:TairaNN | lld:pubmed |
| pubmed-article:2342605 | pubmed:author | pubmed-author:YanagisawaTT | lld:pubmed |
| pubmed-article:2342605 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2342605 | pubmed:volume | 341 | lld:pubmed |
| pubmed-article:2342605 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2342605 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2342605 | pubmed:pagination | 251-5 | lld:pubmed |
| pubmed-article:2342605 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:meshHeading | pubmed-meshheading:2342605-... | lld:pubmed |
| pubmed-article:2342605 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2342605 | pubmed:articleTitle | Phorbol 12,13-dibutyrate increases vascular tone but has a dual action on intracellular calcium levels in porcine coronary arteries. | lld:pubmed |
| pubmed-article:2342605 | pubmed:affiliation | Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan. | lld:pubmed |
| pubmed-article:2342605 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2342605 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2342605 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2342605 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2342605 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2342605 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2342605 | lld:pubmed |
