Linked Life Data

2339917

Source:http://linkedlifedata.com/resource/pubmed/id/2339917

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-6-18
pubmed:abstractText
Melanoma is often diagnosed in young adults, a significant proportion of whom are women of child-bearing age. The prognosis of women diagnosed with melanoma during a pregnancy continues to be debated. One hundred patients, ages 19 to 40 years, have been identified who were pregnant at the time of diagnosis of their melanoma. All were treated with local excision. Sixteen per cent underwent elective lymph node dissections. Immunotherapy was administered to 83% of patients. Mean follow-up was 6.8 years from the date of diagnosis. The patients were compared to an age-matched group of 86 women who were not pregnant at the time of diagnosis. Overall mortality during the follow-up period was 25% in the pregnant group and 23% in the control group. Among the pregnant group, there was an increased incidence of lymph node metastases during the follow-up period (39% versus 26%, p = 0.053). Among stage I patients, there was a significantly shorter DFI for the pregnant group (p = 0.039), with 50% of pregnant patients and 67% of control patients free of disease at 10 years. Similarly, among stage 1 patients, the time to development of lymph node metastases was shorter in the pregnant group (p = 0.021). Multivariate analysis demonstrated that pregnancy at diagnosis was significantly associated with the development of metastatic disease (p = 0.008), when controlling for tumor site, thickness, and Clark level. Patients who developed melanoma during pregnancy did not, however, have a significant decrease in survival.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-1247953, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-13784837, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-13827359, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-14821926, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-3738179, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-3971302, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-485611, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-6159960, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-679159, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-6834839, http://linkedlifedata.com/resource/pubmed/commentcorrection/2339917-7237410
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0003-4932
pubmed:author
pubmed:issnType
Print
pubmed:volume
211
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
552-7; discussion 558-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Malignant melanoma arising during pregnancy. A study of 100 patients.
pubmed:affiliation
Department of Surgery, Duke University Medical Center, Durham, NC 27710.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.