Linked Life Data

2339412

Source:http://linkedlifedata.com/resource/pubmed/id/2339412

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-6-18
pubmed:abstractText
Cephaloridine produces proximal tubular necrosis in the rabbit kidney. Calcium channel blockers have ameliorated tissue injury due to toxic and ischemic insults. To determine whether renal damage caused by cephaloridine could be modified by pretreatment with verapamil, groups of rabbits were given cephaloridine, 100 mg/kg sc, 90 min after administration of verapamil, 200 micrograms/kg iv. Histologic scoring of the extent of proximal tubular necrosis 48 h later demonstrated increased necrosis in the group receiving verapamil plus cephaloridine. Verapamil pretreatment increased the concentration of cephaloridine in the renal cortex at 0.5 hr, but did not alter the peak concentration (2 hr after the dose) or cortical concentrations at 1 or 3 hr. Assay of total calcium content in cortical mitochondria 2 hr after cephaloridine showed that verapamil pretreatment abolished the increased accumulation following cephaloridine administration. We conclude that verapamil does not protect renal proximal tubular cells from the toxic effect of cephaloridine, and that verapamil prevents the cephaloridine-induced uptake of calcium by cortical mitochondria.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
383-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effect of verapamil on cephaloridine nephrotoxicity in the rabbit.
pubmed:affiliation
Department of Pediatrics, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
pubmed:publicationType
Journal Article