Linked Life Data

2339156

Source:http://linkedlifedata.com/resource/pubmed/id/2339156

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-6-18
pubmed:abstractText
Total caloric intake and patterns of dietary self-selection of the three macronutrients, protein, carbohydrate and fat, were examined in adult male rats maintained on a 6-hr feeding schedule following daily injections of morphine (10 mg/kg), naloxone (1 mg/kg), the two drugs together, and saline. Animals received drug injections for 10 consecutive days. All animals received saline injections for the 5 days preceding and 5 days following the experimental period. Naloxone injections led to a significant reduction in total caloric intake. Neither morphine nor morphine and naloxone together significantly affected total caloric intake. Each of the drugs had a distinct effect on macronutrient selection. Morphine produced a significant increase in fat intake and decrease in carbohydrate intake, while naloxone led to a slight reduction in fat intake. When the two drugs were given together, a significant elevation in carbohydrate intake and reduction in fat intake were observed. Protein intake was not affected by any of the drugs. These results are discussed with respect to the hypothesized role of the endogenous opioid system in the regulation of energy balance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
665-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Diet selection following a chronic morphine and naloxone regimen.
pubmed:affiliation
Institute of Human Nutrition, Columbia University, New York.
pubmed:publicationType
Journal Article