Linked Life Data

2339005

Source:http://linkedlifedata.com/resource/pubmed/id/2339005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-6-20
pubmed:abstractText
Insulin-dependent diabetes mellitus (IDDM) is associated with several complications, including painful diabetic neuropathy. Both animal and human investigations suggest an altered pain response in IDDM. Furthermore, it has been suggested that glucose may be an important mediating factor in these painful symptoms. In the present study, pain threshold was assessed via tail flick latency in alloxan-diabetic and control rats. In addition, tail flick latency was determined under conditions of both hyperglycemia and euglycemia in diabetic rats. Conditions of hyperglycemia resulted in a significant decrease in the tail flick latency of alloxan-diabetic rats. In contrast, tail flick latency was significantly increased in diabetic rats following normalization of blood glucose levels. It is concluded that elevated blood glucose levels contribute to a decrease in pain threshold in alloxan-diabetic rats.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3959
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effect of hyperglycemia on pain threshold in alloxan-diabetic rats.
pubmed:affiliation
Department of Psychology, University of Virginia, Charlottesville 22903.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.