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pubmed-article:2337289pubmed:abstractTextAn in vitro bioassay system was used to study the effects of cyclopiazonic acid (CPA) mycotoxin on cardiac muscle. Acute exposure to 6 micrograms of CPA/ml of modified Krebs-Henseleit solution significantly (P less than 0.05) decreased 5 in vitro turkey cardiac muscle performance criteria: maximal weight a muscle could lift; maximal contraction velocity; relaxation velocity; time to peak contraction; and total time for muscle contraction and relaxation. The effect on these 5 criteria appeared to result from intracellular changes partially associated with calcium availability and were irreversible, suggesting that physiologic changes had developed after acute exposure to CPA.lld:pubmed
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pubmed-article:2337289pubmed:authorpubmed-author:RichardJ LJLlld:pubmed
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pubmed-article:2337289pubmed:year1990lld:pubmed
pubmed-article:2337289pubmed:articleTitleIn vitro effects of cyclopiazonic acid mycotoxin on turkey papillary muscles.lld:pubmed
pubmed-article:2337289pubmed:affiliationUSDA, Agricultural Research Service, National Animal Disease Center, Ames, IA 50010.lld:pubmed
pubmed-article:2337289pubmed:publicationTypeJournal Articlelld:pubmed