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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1990-6-12
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pubmed:abstractText |
To study whether exposure to low levels of vinyl chloride monomer (VCM) causes increased risk for cancer morbidity and death from ischemic heart disease, a cohort study was performed among 2,031 male workers at a polyvinyl chloride (PVC) processing plant who had been employed for at least 3 months during the period 1945-1980. An almost significantly increased total mortality (SMR = 116, 95% CI 99-136) was found. Deaths caused by violence or intoxication were significantly increased (SMR = 153, 95% CI 109-213), but not deaths from ischemic heart disease (SMR = 100, 95% CI 73-135). A significant increase in total cancer morbidity was observed (SMR = 128, 95% CI 101-161). Respiratory cancers were significantly increased (SMR = 213, 95% CI 127-346). Furthermore, six brain tumors (vs. 2.6 expected) were observed. This increase, however, was not significant (SMR = 229, 95% CI 84-498). No liver hemangiosarcoma was observed. Applying a latency period of greater than or equal to 10 years from start of employment did not change the risk patterns. There were no significant exposure-response associations between exposure estimates for VCM, asbestos, and plasticizers and cancer morbidity.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0271-3586
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
553-65
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2337081-Adult,
pubmed-meshheading:2337081-Aged,
pubmed-meshheading:2337081-Cardiovascular Diseases,
pubmed-meshheading:2337081-Chemical Industry,
pubmed-meshheading:2337081-Cohort Studies,
pubmed-meshheading:2337081-Humans,
pubmed-meshheading:2337081-Incidence,
pubmed-meshheading:2337081-Lung Diseases, Obstructive,
pubmed-meshheading:2337081-Male,
pubmed-meshheading:2337081-Middle Aged,
pubmed-meshheading:2337081-Neoplasms,
pubmed-meshheading:2337081-Occupational Diseases,
pubmed-meshheading:2337081-Risk,
pubmed-meshheading:2337081-Survival Rate,
pubmed-meshheading:2337081-Sweden,
pubmed-meshheading:2337081-Vinyl Chloride,
pubmed-meshheading:2337081-Vinyl Compounds
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pubmed:year |
1990
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pubmed:articleTitle |
Mortality and cancer morbidity in workers exposed to low levels of vinyl chloride monomer at a polyvinyl chloride processing plant.
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pubmed:affiliation |
Department of Occupational Medicine, University Hospital, Lund, Sweden.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|