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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1984-5-2
|
| pubmed:abstractText |
Forty patients with hypocalcemia and/or Albright's hereditary osteodystrophy were studied. Based on the estimation of serum calcium and parathyroid hormone (PTH) levels as well as the urinary cAMP response to infusions with parathyroid extract, it was possible to classify all of the patients studied as cases with idiopathic hypoparathyroidism (n = 6, low PTH, normal cAMP response), pseudohypoparathyroidism (PHP) type I (n = 18, high PTH, low cAMP response) and type II (n = 2, high PTH, normal cAMP response), as well as pseudopseudohypoparathyroidism (n = 14, normal PTH, normal cAMP response). In three cases studied at the age of 12, 17, and 23 yr, the signs of Albright's hereditary osteodystrophy were not observed. PTH levels were unusually high for a given serum calcium concentration in some patients with PHP, the increased PTH levels were, however, normalized during iv calcium infusions. In two young children with PHP, a gradual increase of serum PTH levels occurred despite persistent normocalcemia over a period of 3 yr. This suggests that factors other than hypocalcemia or frequent small unobservable falls of the serum calcium concentration, such as a deficient formation of 1,25-dihydroxyvitamin D3, secretion of an abnormal PTH, or an abnormal metabolism of the hormone, may contribute to the secondary hyperparathyroidism in PHP.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0021-972X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
872-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:233700-Adolescent,
pubmed-meshheading:233700-Adult,
pubmed-meshheading:233700-Calcium,
pubmed-meshheading:233700-Child,
pubmed-meshheading:233700-Child, Preschool,
pubmed-meshheading:233700-Cyclic AMP,
pubmed-meshheading:233700-Diagnosis, Differential,
pubmed-meshheading:233700-Female,
pubmed-meshheading:233700-Humans,
pubmed-meshheading:233700-Hypocalcemia,
pubmed-meshheading:233700-Hypoparathyroidism,
pubmed-meshheading:233700-Infant,
pubmed-meshheading:233700-Male,
pubmed-meshheading:233700-Middle Aged,
pubmed-meshheading:233700-Parathyroid Glands,
pubmed-meshheading:233700-Parathyroid Hormone,
pubmed-meshheading:233700-Pseudohypoparathyroidism,
pubmed-meshheading:233700-Tissue Extracts
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Pseudohypoparathyroidism and idiopathic hypoparathyroidism: relationship between serum calcium and parathyroid hormone levels and urinary cyclic adenosine-3',5'-monophosphate response to parathyroid extract.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|