Linked Life Data

2336202

Source:http://linkedlifedata.com/resource/pubmed/id/2336202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-6-8
pubmed:abstractText
Involvement of the GABAergic nigro-collicular pathway in the control of audiogenic seizures was examined in genetically sensitive rats by studying the effects of bilateral injections into the substantia nigra of muscimol, a gamma-Aminobutyric acid (GABA) agonist, and those of bilateral injections into the superior colliculus of picrotoxin, a GABA antagonist, and of muscimol. Microinjections of muscimol (20-80 ng/side) into the substantia nigra and microinjections into the superior colliculus of picrotoxin (20 and 40 ng/side) both failed to suppress audiogenic seizures. Following injections into the superior colliculus, audiogenic seizures were in fact facilitated by picrotoxin and suppressed by muscimol. These results suggest that the nigro-collicular GABAergic pathway is not involved in the inhibitory control over audiogenic seizures. Conversely, a different GABAergic mechanisms may be involved in the superior colliculus in the control of this form of epilepsy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
111
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-74
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
The GABAergic nigro-collicular pathway is not involved in the inhibitory control of audiogenic seizures in the rat.
pubmed:affiliation
Departement de Neurophysiologie et Biologie des Comportements, CNRS, Strasbourg, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't