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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1990-6-6
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pubmed:abstractText |
Laser myopic keratomileusis (photorefractive keratectomy) was performed on 29 rhesus monkey corneas with an argon fluoride (193-nm) excimer laser and a computer-controlled, moving slit delivery system. The 4-mm-diameter central ablation zone ranged in depth from 11 microns (-2 diopters effect) to 46 microns (-8 diopters effect). Corneas were studied for the 9 months postoperatively by clinical slit-lamp microscopy, and periodically with light and transmission electron microscopy. By 6 weeks, mild to moderate subepithelial haze was apparent in 93% of the corneas, with considerable variability in density. Progressive clearing occurred so that by 6 to 9 months 12 of 13 surviving corneas (92%) were either completely clear (4 corneas) or trace hazy (8 corneas). The epithelium was thickened at 21 days after ablation and returned to normal thickness by 3 months. At 3 weeks, subepithelial fibroblasts were three times the density of normal keratocytes and returned to nearly normal numbers by 9 months. We concluded that the anterior monkey cornea demonstrated a mild, typical wound healing response after excimer laser keratomileusis.
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pubmed:grant | |
pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0003-9950
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
665-75
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2334323-Animals,
pubmed-meshheading:2334323-Cornea,
pubmed-meshheading:2334323-Corneal Opacity,
pubmed-meshheading:2334323-Corneal Stroma,
pubmed-meshheading:2334323-Epithelium,
pubmed-meshheading:2334323-Follow-Up Studies,
pubmed-meshheading:2334323-Laser Therapy,
pubmed-meshheading:2334323-Macaca mulatta,
pubmed-meshheading:2334323-Refractive Surgical Procedures,
pubmed-meshheading:2334323-Wound Healing
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pubmed:year |
1990
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pubmed:articleTitle |
Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeys.
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pubmed:affiliation |
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Ga. 30322.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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