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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1990-5-29
|
| pubmed:abstractText |
A series of tetraamines derived from 1,8-diaminooctane was prepared and tested as antitumor agents. The reaction of 1,8-diaminooctane with acrylonitrile gave N,N'-bis(cyanoethyl)-1,8-diaminooctane, which was reduced to tetraamine 20. Alkylation of the terminal nitrogen atoms of the tetra-Boc derivative of this compound by methyl or ethyl halide followed by removal of the Boc groups gave the bis(alkyl)polyamines 26a and 26b, respectively. These three compounds exhibit promising antitumor activity in the mouse L1210 leukemia model. Coadministration of a polyamine oxidase inhibitor potentiated the antitumor activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1369-75
|
| pubmed:dateRevised |
2011-11-2
|
| pubmed:meshHeading |
pubmed-meshheading:2329556-Animals,
pubmed-meshheading:2329556-Antineoplastic Agents,
pubmed-meshheading:2329556-Chemical Phenomena,
pubmed-meshheading:2329556-Chemistry,
pubmed-meshheading:2329556-Leukemia L1210,
pubmed-meshheading:2329556-Mice,
pubmed-meshheading:2329556-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:2329556-Polyamines,
pubmed-meshheading:2329556-Structure-Activity Relationship
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Polyamine analogues with antitumor activity.
|
| pubmed:affiliation |
Merrell Dow Research Institute, Cincinnati, Ohio 45215.
|
| pubmed:publicationType |
Journal Article
|