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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1990-5-24
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pubmed:abstractText |
Osteoinductive factor (OIF) is a glycoprotein in bone that induces ectopic bone formation. Implantation of OIF plus transforming growth factor beta (TGF-beta) type 1 or 2 into subcutaneous tissues of rats induces formation of bone at the implantation site. Since TGF-beta is also present in bone matrix and inhibits formation of multinucleated cells that express an osteoclast phenotype in long-term human marrow cultures, we tested the effects of OIF on formation of these osteoclast-like cells to determine the effects of OIF on cells in the osteoclast lineage. We found that OIF inhibited total multinucleated cell (MNC) formation in a dose-dependent fashion and preferentially inhibited formation of MNCs that react with monoclonal antibody 23c6 (23c6-positive MNCs), an antibody that identifies osteoclasts. In addition, low concentrations of OIF in combination with low concentrations of TGF-beta acted synergistically to inhibit 23c6-positive MNC formation. The inhibition of 23c6-positive MNC formation by OIF was not mediated by prostaglandin synthesis. These data suggest that regulatory growth factors, such as OIF or TGF-beta, that are stored within the bone matrix and released when bone is resorbed can serve as natural inhibitors of osteoclast activity by inhibiting osteoclast formation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-2468824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-2584240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-2783589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-2785743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-2871553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3106013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-310676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3165196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3332553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3345718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3469199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3471760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3489738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3491081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3494250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3497030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3569133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3857579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3859875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3865222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-3882116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-4053038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-6572416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-6602130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-6602340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2326263-6607069
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3023-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2326263-Alprostadil,
pubmed-meshheading:2326263-Bone Development,
pubmed-meshheading:2326263-Bone Marrow Cells,
pubmed-meshheading:2326263-Calcitonin,
pubmed-meshheading:2326263-Cells, Cultured,
pubmed-meshheading:2326263-Dinoprostone,
pubmed-meshheading:2326263-Glycoproteins,
pubmed-meshheading:2326263-Humans,
pubmed-meshheading:2326263-Indomethacin,
pubmed-meshheading:2326263-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:2326263-Osteoclasts,
pubmed-meshheading:2326263-Transforming Growth Factors
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pubmed:year |
1990
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pubmed:articleTitle |
Osteoinductive factor inhibits formation of human osteoclast-like cells.
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pubmed:affiliation |
Research Service and Geriatric Research, Education and Clinical Center, Audie Murphy Veterans Administration Hospital, San Antonio, TX.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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