| pubmed-article:2323368 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2323368 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:2323368 | lifeskim:mentions | umls-concept:C0302090 | lld:lifeskim |
| pubmed-article:2323368 | lifeskim:mentions | umls-concept:C0230445 | lld:lifeskim |
| pubmed-article:2323368 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:2323368 | lifeskim:mentions | umls-concept:C0017817 | lld:lifeskim |
| pubmed-article:2323368 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2323368 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:2323368 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:2323368 | lifeskim:mentions | umls-concept:C0439282 | lld:lifeskim |
| pubmed-article:2323368 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2323368 | pubmed:dateCreated | 1990-5-17 | lld:pubmed |
| pubmed-article:2323368 | pubmed:abstractText | We isolated a peptide from calf spleen that specifically inhibits murine granulopoiesis in vitro. Human T-lymphocyte colony growth was not affected. Formation of erythroid colony-forming units (CFU-E) was only slightly inhibited at a concentration 1000-fold higher compared to granulocyte-macrophage colony-forming cell (GM-CFC) assay. After high performance liquid chromatography purification we isolated a monomer (reduced peptide) showing the inhibitory activity and a dimer (oxidized peptide) with stimulatory activity. The isolated peptide was identified as glutathione. The reduced form of this well-known tripeptide (GSH) specifically inhibits murine granulopoiesis in vitro at 10(-7)-10(-8) M concentration. Oxidized glutathione (GSSG) stimulates GM-CFC formation; the extent of stimulation depends on the colony-stimulating factor concentration. The striking finding that GSH and GSSG modulate granulopoiesis at nanomolar concentrations requires further studies on the molecular interaction between either peptide with GM-CSF and its receptor protein. | lld:pubmed |
| pubmed-article:2323368 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2323368 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2323368 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2323368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2323368 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2323368 | pubmed:month | May | lld:pubmed |
| pubmed-article:2323368 | pubmed:issn | 0301-472X | lld:pubmed |
| pubmed-article:2323368 | pubmed:author | pubmed-author:MaurerH RHR | lld:pubmed |
| pubmed-article:2323368 | pubmed:author | pubmed-author:FetschJJ | lld:pubmed |
| pubmed-article:2323368 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2323368 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:2323368 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2323368 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2323368 | pubmed:pagination | 322-5 | lld:pubmed |
| pubmed-article:2323368 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:meshHeading | pubmed-meshheading:2323368-... | lld:pubmed |
| pubmed-article:2323368 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2323368 | pubmed:articleTitle | Glutathione: an in vitro granulopoiesis inhibitor at nanomolar concentration, isolated from calf spleen. | lld:pubmed |
| pubmed-article:2323368 | pubmed:affiliation | Institute for Pharmacy, Free University Berlin, FRG. | lld:pubmed |
| pubmed-article:2323368 | pubmed:publicationType | Journal Article | lld:pubmed |
