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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1990-5-21
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pubmed:abstractText |
Soluble nickel(II) ion, given to male F344/NCr rats as a single i.p. injection of nickel(II) acetate tetrahydrate at a dose of 90 mumols/kg body weight at 5 weeks of age, proved an effective initiator of renal cortical epithelial tumors. The tumors were revealed by subsequent dosing with the known renal tumor promoter, sodium barbital (5,5-diethylbarbituric acid, sodium salt) dissolved in drinking water at a concentration of 500 p.p.m. Only one rat given the nickel injection without subsequent promotion developed a single renal cortical adenoma, while multiple tumors were common in nickel(II) initiated/sodium barbital promoted rats. Renal cortical adenocarcinomas, some of them metastatic to lung, liver, and spleen, occurred only in initiated/promoted rats. No excess incidence of nickel-initiated tumors was found in any other tissues in which sodium barbital is known to promote carcinogenesis, such as liver or thyroid. A single i.p. injection of the Ni(II) salt, 95 mumols/kg, appeared to be associated with an increased concentration of 8-hydroxy-2'-deoxyguanosine in DNA extracted from kidneys of rats 16-48 h after injection.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Barbiturates,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/barbituric acid
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0143-3334
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
647-52
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2323003-Acetic Acid,
pubmed-meshheading:2323003-Acetic Acids,
pubmed-meshheading:2323003-Animals,
pubmed-meshheading:2323003-Barbiturates,
pubmed-meshheading:2323003-Body Weight,
pubmed-meshheading:2323003-Carcinogens,
pubmed-meshheading:2323003-Epithelium,
pubmed-meshheading:2323003-Kidney Cortex,
pubmed-meshheading:2323003-Kidney Neoplasms,
pubmed-meshheading:2323003-Male,
pubmed-meshheading:2323003-Organ Size,
pubmed-meshheading:2323003-Rats,
pubmed-meshheading:2323003-Rats, Inbred F344
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pubmed:year |
1990
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pubmed:articleTitle |
Initiation by nickel acetate and promotion by sodium barbital of renal cortical epithelial tumors in male F344 rats.
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pubmed:affiliation |
Laboratory of Comparative Carcinogenesis, National Cancer Institute, MD 21701.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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