Linked Life Data

2322608

Source:http://linkedlifedata.com/resource/pubmed/id/2322608

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1990-5-21
pubmed:abstractText
Lung tissue from 18-day-old rat fetuses was cultured in the presence of 1,25-dihydroxyvitamin D3 - 1,25(OH)2D3 - (10(-9) M) and dexamethasone (10(-7) M) for 48 h. 1,25(OH)2D3 increased the lung content in phospholipids more specifically related to lung surfactant, phosphatidylcholine and phosphatidylglycerol. This increase was similar to that observed with dexamethasone. In addition, unlike dexamethasone, 1,25(OH)2D3 stimulated the surfactant release into luminal spaces, as evidenced by light and electron microscopy. Thus, vitamin D3 might represent an additional factor controlling fetal lung maturation by stimulating phospholipid synthesis and surfactant release from type II cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0006-3126
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-60
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
1,25(OH)2D3 stimulates phospholipid biosynthesis and surfactant release in fetal rat lung explants.
pubmed:affiliation
CNRS, Centre de Biologie Cellulaire, Ivry-sur-Seine, France.
pubmed:publicationType
Journal Article