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rdf:type |
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lifeskim:mentions |
umls-concept:C0002395,
umls-concept:C0004398,
umls-concept:C0030705,
umls-concept:C0087111,
umls-concept:C0220905,
umls-concept:C0392747,
umls-concept:C0439831,
umls-concept:C0443172,
umls-concept:C0520510,
umls-concept:C0542341,
umls-concept:C0599668,
umls-concept:C1314792,
umls-concept:C1516048
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pubmed:issue |
7
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pubmed:dateCreated |
1990-5-4
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pubmed:abstractText |
Brain regions from patients with or without Alzheimer disease (AD) were obtained within 2 hr of death and examined for indices of presynaptic cholinergic function. Consistent with loss of cholinergic projections, cerebral cortical areas involved in AD exhibited decreased choline acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6) activity. However, remaining nerve terminals in these regions displayed marked up-regulation of synaptosomal high affinity [3H]choline uptake, a result indicative of relative cholinergic hyperactivity. As choline uptake is also rate-limiting in acetylcholine biosynthesis, these findings have implications for both therapy and identification of causes contributing to neuronal death in AD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-1271069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-2863836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-2864910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-3063300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-3120031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-3708340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-3774212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-3877182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-427545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-438818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-6306169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-64712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-6661641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-678975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-6822833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-7082992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2320567-723454
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2452-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1990
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pubmed:articleTitle |
Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy.
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pubmed:affiliation |
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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