Linked Life Data

2317539

Source:http://linkedlifedata.com/resource/pubmed/id/2317539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-5-2
pubmed:abstractText
Various poly (2-hydroxyethyl methacrylate)-collagen and poly (glyceryl methacrylate)-collagen composite hydrogels with varying porosities and cross-linking densities were implanted into the cortex of adult rat brains to provide mechanical guiding substrates for wound healing and tissue ingrowth. The hydrogels were well tolerated by the neural tissue. After 2 and 3 month, hyper- and macroporous hydrogels (poly(glyceryl methacrylate)) with interconnected channel systems were penetrated by neural tissue and elements of extracellular matrices, with differences in the degree and the topographic patterning of tissue ingrowth according to the type of samples. These differences were ascribed to the geometry, size of the pore interconnections and the mechanical properties of the polymers. Hyper- and microporous hydrogels (poly(2-hydroxyethyl methacrylate)) and hydrogels without collagen were not penetrated by the host tissue. The compatibility of the polymers with the neural tissue was also tested in vitro. This study suggests a new approach to repair brain lesions consisting of loss of tissue volume.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-107
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Intracerebral implantation of synthetic polymer/biopolymer matrix: a new perspective for brain repair.
pubmed:affiliation
Laboratoire de Neurobiologie, Hôpital de l'Enfant-Jésus et Université Laval, Québec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't