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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1990-5-3
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pubmed:abstractText |
The peptide fraction extracted by methanol from the skin of Rana esculenta, a species widely distributed in Western Europe, was investigated. The pharmacological activity found in the extract is attributable to the presence of authentic bradykinin, together with a shorter, partially active version of this molecule, des-Arg9-bradykinin. Also the bradykinin fragment 1-7 has been isolated, but it was inactive in our bioassay system. Moreover, a family of hydrophobic peptides has been purified and characterized, which appeared devoid of pharmacological activities when tested on smooth muscle preparations, but were provided with hemolytic activities.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
1033
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
318-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2317508-Amino Acid Sequence,
pubmed-meshheading:2317508-Animals,
pubmed-meshheading:2317508-Bradykinin,
pubmed-meshheading:2317508-Chromatography, High Pressure Liquid,
pubmed-meshheading:2317508-Chromatography, Thin Layer,
pubmed-meshheading:2317508-Hemolysis,
pubmed-meshheading:2317508-Humans,
pubmed-meshheading:2317508-Molecular Sequence Data,
pubmed-meshheading:2317508-Peptides,
pubmed-meshheading:2317508-Protein Conformation,
pubmed-meshheading:2317508-Rana esculenta,
pubmed-meshheading:2317508-Skin
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pubmed:year |
1990
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pubmed:articleTitle |
Purification and characterization of bioactive peptides from skin extracts of Rana esculenta.
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pubmed:affiliation |
Dipartimento di Scienze Biochimiche, Università La Sapienza, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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