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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3 Pt 2
|
| pubmed:dateCreated |
1990-4-23
|
| pubmed:abstractText |
This study was designed to determine whether cardiac vagal afferents exert an inhibitory influence on increases in regional vascular resistance during exercise and to determine whether endurance exercise training enhances the inhibitory influence of cardiac vagal afferents. We measured changes in regional vascular resistance in 12 rabbits at rest and during running at 12.6 m/min, 20% grade, before and after reversible denervation of cardiac afferents (intrapericardial procainamide HCl, 2%). In addition, these procedures were repeated in five of these rabbits following an 8-wk endurance exercise training program. Because intrapericardial injections of procainamide anesthetize both the efferent as well as the afferent innervation to the heart, it was necessary to determine the effects of blocking the efferent innervation on the regulation of regional vascular resistance during exercise. Rabbits were instrumented with Doppler ultrasonic flow probes around the renal (R), mesenteric (M), ascending, and terminal aortic (TA) arteries. Catheters were positioned in the central ear artery and vein and pericardial sac. Mean arterial pressure, heart rate, cardiac output, R, M, TA, and systemic (S) resistances were determined. Exercise changed R (+37 +/- 4%), M (+88 +/- 9%), TA (-62 +/- 6%), and S (-34 +/- 3) resistances. Subsequent cardiac efferent blockade alone had no significant effect on regional vascular resistance during exercise. Combined efferent and afferent blockade resulted in significant increases in R (+62 +/- 6%) and M resistance (+134 +/- 13%) but did not alter TA (-51 +/- 4%) or S (-27 +/- 2%) resistance during exercise. Exercise training significantly enhanced the inhibitory influence of cardiac afferents on R and M regional vascular resistance.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0002-9513
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
258
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
H842-7
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:2316698-Afferent Pathways,
pubmed-meshheading:2316698-Animals,
pubmed-meshheading:2316698-Aorta,
pubmed-meshheading:2316698-Blood Pressure,
pubmed-meshheading:2316698-Efferent Pathways,
pubmed-meshheading:2316698-Heart Conduction System,
pubmed-meshheading:2316698-Heart Rate,
pubmed-meshheading:2316698-Nerve Block,
pubmed-meshheading:2316698-Neurons, Afferent,
pubmed-meshheading:2316698-Physical Conditioning, Animal,
pubmed-meshheading:2316698-Physical Exertion,
pubmed-meshheading:2316698-Rabbits,
pubmed-meshheading:2316698-Renal Circulation,
pubmed-meshheading:2316698-Splanchnic Circulation,
pubmed-meshheading:2316698-Vascular Resistance
|
| pubmed:year |
1990
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| pubmed:articleTitle |
Regional vascular resistance during exercise: role of cardiac afferents and exercise training.
|
| pubmed:affiliation |
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|