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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-4-26
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pubmed:abstractText |
The in vivo effect of amantadine, chlorpromazine and reserpine on testicular aldehyde dehydrogenase (T-ALDH) was studied as a function of mouse strain. The effect of Leu-enkephalin and tetrahydropapaverine on rodent T-ALDH was also studied in vivo. The in vitro effect of chlorpromazine, papaverine and scopolamine on rodent subcellular T-ALDH and testicular alcohol dehydrogenase (T-ADH) were evaluated. A strain-linked difference in endogenous T-ALDH among the three mouse strains studied was determined. Individual injection of chlorpromazine or reserpine inhibited only albino ICR T-ALDH which was alleviated by pretreatment with amantadine and, thereby, suggesting antagonism between amantadine and these agents. The Leu-enkephalin administration induced T-ALDH from saline control. Tetrahydropapaverine did not influence the enzymes studied in vivo compared to an insignificant in vitro induction of T-ADH by the O-methylated analogue papaverine. Chlorpromazine noncompetitively inhibited T-ADH in vitro. The results indicate the modulation of the enzymes studied, which are involved in both detoxification of ethanol and biogenic amine-derived aldehyde intermediates, by agents affecting the endocrine system. This suggests the potential of these testicular enzymes in the evaluation of alcohol- and drug-induced endocrine adverse reactions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alcohol Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Aldehyde Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Amantadine,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorpromazine,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Papaverine,
http://linkedlifedata.com/resource/pubmed/chemical/Psychotropic Drugs,
http://linkedlifedata.com/resource/pubmed/chemical/Reserpine,
http://linkedlifedata.com/resource/pubmed/chemical/Scopolamine Hydrobromide
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0091-3057
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-33
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2315366-Alcohol Dehydrogenase,
pubmed-meshheading:2315366-Aldehyde Dehydrogenase,
pubmed-meshheading:2315366-Amantadine,
pubmed-meshheading:2315366-Animals,
pubmed-meshheading:2315366-Chlorpromazine,
pubmed-meshheading:2315366-Enkephalin, Leucine,
pubmed-meshheading:2315366-Epididymis,
pubmed-meshheading:2315366-Isoquinolines,
pubmed-meshheading:2315366-Male,
pubmed-meshheading:2315366-Mice,
pubmed-meshheading:2315366-Mice, Inbred BALB C,
pubmed-meshheading:2315366-Mice, Inbred C57BL,
pubmed-meshheading:2315366-Mice, Inbred ICR,
pubmed-meshheading:2315366-Papaverine,
pubmed-meshheading:2315366-Psychotropic Drugs,
pubmed-meshheading:2315366-Rats,
pubmed-meshheading:2315366-Rats, Inbred Strains,
pubmed-meshheading:2315366-Reserpine,
pubmed-meshheading:2315366-Scopolamine Hydrobromide,
pubmed-meshheading:2315366-Species Specificity,
pubmed-meshheading:2315366-Testis
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pubmed:year |
1990
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pubmed:articleTitle |
Gonadal alcohol and aldehyde dehydrogenase: in vivo and in vitro effects of psychoactive and endocrine agents.
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pubmed:affiliation |
Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX.
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pubmed:publicationType |
Journal Article
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