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pubmed-article:2314472pubmed:abstractTextTransgenic mice containing a human fetal (gamma-) or adult (beta-) globin gene linked to the beta-globin gene locus activation region (LAR) express the gene throughout development. By contrast, transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the gamma- or beta-globin gene, resulting in the expression of only one gene at any given moment.lld:pubmed
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pubmed-article:2314472pubmed:articleTitleDevelopmental regulation of human fetal-to-adult globin gene switching in transgenic mice.lld:pubmed
pubmed-article:2314472pubmed:affiliationDepartment of Medicine, University of Washington, Seattle 98195.lld:pubmed
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