Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6264
|
| pubmed:dateCreated |
1990-4-26
|
| pubmed:abstractText |
Transgenic mice containing a human fetal (gamma-) or adult (beta-) globin gene linked to the beta-globin gene locus activation region (LAR) express the gene throughout development. By contrast, transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the gamma- or beta-globin gene, resulting in the expression of only one gene at any given moment.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
22
|
| pubmed:volume |
344
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
309-13
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2314472-Animals,
pubmed-meshheading:2314472-Blotting, Southern,
pubmed-meshheading:2314472-DNA, Recombinant,
pubmed-meshheading:2314472-Erythropoiesis,
pubmed-meshheading:2314472-Gene Expression Regulation,
pubmed-meshheading:2314472-Gestational Age,
pubmed-meshheading:2314472-Globins,
pubmed-meshheading:2314472-Humans,
pubmed-meshheading:2314472-Mice,
pubmed-meshheading:2314472-Mice, Transgenic,
pubmed-meshheading:2314472-Regulatory Sequences, Nucleic Acid
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.
|
| pubmed:affiliation |
Department of Medicine, University of Washington, Seattle 98195.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|