Linked Life Data

231403

Source:http://linkedlifedata.com/resource/pubmed/id/231403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1980-4-26
pubmed:abstractText
Prostaglandins serve an important regulatory role in immune responses. Much of their activity seems to involve regulating the early stages of lymphocyte or macrophage activation. Besides the capacity of prostaglandins to control lymphocyte activation directly by blocking transformation, at least one type, PGE2 can induce a class of glass-adherent T-cells to produce a suppressive peptide in vitro. The data we have obtained suggest the existence of a feedback loop in which PG production by an activated T-cell serves as the signal that induces a second T-cell to release a suppressor peptide. This peptide can then regulate the ability of the activated T-cell to pass through the cell cycle. Other examples of feedback loops have recently been postulated or shown to exist among immunocompetent cells. It remains to be shown how these various regulatory loops combine to form the integrated network that modulates immunoresponsiveness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
332
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
262-70
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Endogenous prostaglandin synthesis and the control of lymphocyte function.
pubmed:publicationType
Journal Article, Review