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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1990-4-13
|
| pubmed:abstractText |
HLA-DR expression, lymphocyte subsets, and the distribution of proliferating cells were studied in hyperplastic polyps from the colorectum. The density of T-cells (CD5+) (mean of cells/mm2 of tissue +/- SEM) was higher in the lamina propria of hyperplastic polyps (64.2 +/- 4.2) than in normal colonic mucosa (36.7 +/- 2.6, P less than .001). The CD4/CD8 ratio was higher in hyperplastic polyps (6.3 +/- 0.9, P less than .0001) and in colonic adenomas (5.9 +/- 0.9, P less than .001) compared with normal mucosa (2.3 +/- 0.2). Lymphocytes of the lamina propria were never Ki-67 positive either in normal mucosa or in hyperplastic polyps or adenomas. The epithelial layer of hyperplastic polyps and of normal mucosa did not express the HLA-DR antigen, whereas pericryptal fibroblasts and most of the leukocytes of the lamina propria were strongly positive for this antigen. In the epithelial layer proliferating cells were localized exclusively in the lower part of epithelial crypts, as was the case in normal mucosa, whereas in adenomas Ki-67-positive cells were present throughout the entire height of the mucosa. Thus, in hyperplastic polyps lymphocytes are increased in the lamina propria, with a predominance of the CD4 subset in close contact with HLA-DR positive pericryptal fibroblasts.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0046-8177
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
319-24
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2312108-Adenoma,
pubmed-meshheading:2312108-Aged,
pubmed-meshheading:2312108-Antigens, Surface,
pubmed-meshheading:2312108-Cell Division,
pubmed-meshheading:2312108-Colonic Neoplasms,
pubmed-meshheading:2312108-Epithelium,
pubmed-meshheading:2312108-HLA Antigens,
pubmed-meshheading:2312108-HLA-DR Antigens,
pubmed-meshheading:2312108-Humans,
pubmed-meshheading:2312108-Hyperplasia,
pubmed-meshheading:2312108-Intestinal Mucosa,
pubmed-meshheading:2312108-Intestinal Polyps,
pubmed-meshheading:2312108-Ki-67 Antigen,
pubmed-meshheading:2312108-Middle Aged,
pubmed-meshheading:2312108-Phenotype,
pubmed-meshheading:2312108-T-Lymphocytes
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Expression of histocompatibility antigens and characterization of the lymphocyte infiltrate in hyperplastic polyps of the large bowel.
|
| pubmed:affiliation |
Laboratoire d'Anatomie Pathologique, Hopital Antoine Béclère, Clamart, France.
|
| pubmed:publicationType |
Journal Article
|