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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-4-26
|
| pubmed:abstractText |
Wistar male rats, 3-4 months old, were made to breathe for 6 h a sub-lethal hypoxic atmosphere consisting of 8% oxygen and 92% nitrogen. Following this treatment, these rats were subjected to a series of behavioral and biochemical tests starting 30 days and ending at about 180 days after the hypoxic insult. an age-matched control group was subjected to the same series of tests. The following findings were made at the time interval indicated, relative to controls: (1) At 30-35 days, diurnal (3 h) and nocturnal (12 h) locomotor activities decreased by about 25%. (2) At 40-45 days, amphetamine in the dose range of 0.25-1 mg/kg proved less effective in eliciting an increase in motor activity and stereotypic behavior. (3) At about 50 days, apomorphine in the dose range 0.25-0.5 mg/kg caused an increase in stereotypic behavior. (4) At 60-65 days, alpha-methyl-p-tyrosine at the dose of 50 mg/kg caused a more pronounced hypoactive syndrome and a slower rate of recovery of motor activity. (5) At 75-90 days, performance in the active avoidance test was inferior to that of controls. (6) At 180 days, and one hour after a dose of 200 mg/kg alpha-methyl-p-tyrosine, the turnover rates of hippocampal norepinephrine and caudate-putamen dopamine were much below control. One may tentatively conclude that one of the effects of hypoxia in adult rats is a lesion producing long-term behavioral disorders which are partly ascribed to dopaminergic and, possibly noradrenergic, dysfunction.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apomorphine,
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/Dextroamphetamine,
http://linkedlifedata.com/resource/pubmed/chemical/Methyltyrosines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cholinergic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-methyltyrosine methyl ester
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0166-4328
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
12
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
19-27
|
| pubmed:dateRevised |
2006-3-1
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| pubmed:meshHeading |
pubmed-meshheading:2310491-Age Factors,
pubmed-meshheading:2310491-Animals,
pubmed-meshheading:2310491-Apomorphine,
pubmed-meshheading:2310491-Avoidance Learning,
pubmed-meshheading:2310491-Behavior, Animal,
pubmed-meshheading:2310491-Catecholamines,
pubmed-meshheading:2310491-Caudate Nucleus,
pubmed-meshheading:2310491-Dextroamphetamine,
pubmed-meshheading:2310491-Dopamine,
pubmed-meshheading:2310491-Hippocampus,
pubmed-meshheading:2310491-Hypoxia, Brain,
pubmed-meshheading:2310491-Male,
pubmed-meshheading:2310491-Mental Recall,
pubmed-meshheading:2310491-Methyltyrosines,
pubmed-meshheading:2310491-Motor Activity,
pubmed-meshheading:2310491-Putamen,
pubmed-meshheading:2310491-Rats,
pubmed-meshheading:2310491-Rats, Inbred Strains,
pubmed-meshheading:2310491-Receptors, Cholinergic,
pubmed-meshheading:2310491-Receptors, Dopamine,
pubmed-meshheading:2310491-Stereotyped Behavior
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Central catecholaminergic dysfunction and behavioural disorders following hypoxia in adult rats.
|
| pubmed:affiliation |
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
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| pubmed:publicationType |
Journal Article
|