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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4946
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pubmed:dateCreated |
1990-4-4
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pubmed:abstractText |
Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human beta-polymerase (hu beta-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
247
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1082-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2309119-Base Sequence,
pubmed-meshheading:2309119-Cell Line,
pubmed-meshheading:2309119-Cell Line, Transformed,
pubmed-meshheading:2309119-DNA, Viral,
pubmed-meshheading:2309119-DNA Polymerase I,
pubmed-meshheading:2309119-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:2309119-Gene Expression Regulation, Viral,
pubmed-meshheading:2309119-Human T-lymphotropic virus 1,
pubmed-meshheading:2309119-Humans,
pubmed-meshheading:2309119-Molecular Sequence Data,
pubmed-meshheading:2309119-Plasmids,
pubmed-meshheading:2309119-Promoter Regions, Genetic,
pubmed-meshheading:2309119-RNA, Messenger,
pubmed-meshheading:2309119-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:2309119-Repressor Proteins,
pubmed-meshheading:2309119-Trans-Activators,
pubmed-meshheading:2309119-Transcription Factors,
pubmed-meshheading:2309119-Transfection
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pubmed:year |
1990
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pubmed:articleTitle |
HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene.
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pubmed:affiliation |
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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